Question

Second-generation vaccines are prepared by recombinant DNA technology. Which out of the following are the examples of such vaccines?
A. Hepatitis B Virus vaccine
B. Herpes virus vaccine
C. Salk’s polio vaccine
D. Both A and B

Answer 1

Hint: Polio vaccine contains a heat-killed poliovirus. Heat killed vaccines contain organisms which are dead.

Complete Answer:
- Recombinant DNA technology is a process wherein a foreign piece of DNA is introduced to the DNA of the other species cell. This other species cell is called a vector. It is a combination of the DNA of two different species.
- The gene introduced into the genome (DNA) of a vector is called a recombinant gene. This process of introducing a recombinant gene into the genome of the vector cells is called recombinant DNA technology.
- Vaccines produced by recombinant DNA technology are called a second-generation vaccine. - These vaccines do not contain the whole organism instead of it, they contain a part of the organism.
- Examples of Second-generation vaccines are the Hepatitis B virus, Herpes virus, pneumonia vaccine, etc.
- Hepatitis B virus vaccine was the first commercially available human vaccine produced by recombinant DNA technology.

So, the correct answer is D both A and B.

Note: First-generation vaccines are the vaccines that contain live, weakened organisms or heat-killed organisms. Example of first-generation vaccines are:
Poliovirus vaccine: the polio vaccine consists of heat-killed poliovirus.