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Read the statements given below and mark the correct option
 $ 1 $ . Apoenzymes are non-proteinaceous prosthetic enzymes
 $ 2 $ . Bell shaped curve is obtained when enzyme activity is plotted against temperature and pH
 $ 3 $ . Specificity of enzyme is a property of tertiary structure of proteins usually
 $ 4 $ .Enzymes increases the rate of the reaction by altering the equilibrium of the reaction

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Answer
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Hint :Co-factor is the non-protein part of the enzyme. Temperature and pH are the critical parameters which highly influence the enzyme activity. Structure of the protein is decided by the linear chain of amino acids joined together by peptide bonds. Rate of the reaction depends on the activation energy

Complete Step By Step Answer:
Enzyme is composed of protein component and non-protein component
Apoenzyme is the protein part of the enzyme, protein conjugated with other regions to form the complete enzyme
Coenzyme are small molecules, the non-protein part of the enzyme
Apoenzyme and coenzyme holds together to form the complete enzyme
Therefore, the first option is $ 1 $ . Apoenzymes are non-proteinaceous prosthetic enzymes incorrect statement
Primary structure is formed by the linear chain of amino acids join together by peptide bonds
Folding up of linear chain of amino acids to specific sheets, loops thereby forms the secondary structure
Folding up of linear chain of amino acids to $ 3-D $ $ 3-D $ structures to form tertiary structures
Hence, the properties and active site of enzyme depends on the primary structure
Active site takes the responsibility of specificity of the enzyme
Therefore, specificity of enzyme depends on primary structure, active site and peptide bonds
Therefore, $ 3 $ . Specificity of enzyme is a property of tertiary structure of proteins usually is incorrect statement
Enzymes increases the rate of the reaction by lowering the activation energy
Enzymes generally do not modify the equilibrium state of the reaction
Enzymes always modifies the activation energy
Therefore, $ 4 $ .Enzymes increases the rate of the reaction by altering the equilibrium of the reaction is incorrect statement
pH and Temperature are critical parameters
Change in specific pH and temperature affects the velocity and bell shaped curve is obtained
Therefore, a Bell shaped curve is obtained when enzyme activity is plotted against temperature and pH is the correct statement.

Note :
Alkaline pH may denature the enzyme. Lower temperature affects the rate of the reaction. Specific pH and temperature are required. When enzyme activity of pH and temperature are plotted, we obtain bell shaped curves.