Question

Parkinson's disease is caused due to deficiency of?
A) GABA
B) Endorphins
C) Dopamine
D) Acetylcholine

Answer 1

Hint: Dopamine is a molecule that does not directly activate ion-channel receptors but that act together with neurotransmitters, enhancing excitatory or inhibitory responses of the receptors. It is often impossible to determine, in the presence of many substances, which are transmitters and which are modulators.

Complete step-by-step answer:

Dopamine plays important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. dopamine is present in 80% of the brain. Parkinson’s disease is a slowly progressive degenerative disease of the nervous system associated with the destruction of brain cells, which produce dopamine. It is named after the discoverer James Parkinson.
It is also called Parkinson/ paralysis agitans. Parkinson’s disease occurs due to a lack of dopamine caused by damage to the basal ganglia. It is mostly due to the destruction of the susbtancia nigra and nigrostriatal pathway which has dopaminergic fibers. Parkinson's disease develops very slowly and early signs and symptoms may be unnoticed for months and years. Often the symptoms start with a mildly noticeable tumor in just one hand. When the tumor is remarkable the disease-causing slowly/freezing movement and slowly causes rigidity.

Therefore the correct answer is Option C.

Note: Great boxer Mohammed Ali is affected by Parkinson's disease because of repeated blows, he might have received on the head resulting in damage to brain cells producing dopamine. If Parkinson's patients drugs are not monitored then schizophrenia disease will occur as in schizophrenia dopamine is produced in excess.