Question

One of the known largest coding gene in human is
A. Dystrophin
B. Hemoglobin
C. Insulin
D. Myoglobin

Answer 1

Hint: Within the individual mitochondria small DNA molecules and 23 pair of the chromosomes that encode with the DNA and complete set of nucleic acids sequence found in the human genome. The mitochondrial genome and nuclear genome both are treated separately during the defect found in the human gene.

Complete answer:
The complete set of nucleic acid sequence for the human encoded as a DNA in the human genome. The signal for the formation of a protein called dystrophy that is the largest coding gene present in the human genome. The full form of the DMD (Duchene muscular dystrophy). The DMD gene covers 2.3 mega bases in the human gene that encoding the dystrophin protein.
Dystrophin is a large protein with molecular mass of 427,000 Da and connects with the thin actin filaments in the smaller proteins called syntrophins attached through the transmembrane beta dystroglycan protein. By the alpha dystroglycan beta dystroglycan is connected to the rosin that refers to the lamininis and contains the alpha 2 subunit.
By providing a scaffolding for the fibrils and connecting with the extracellular matrix dystrophin glycoprotein adds the strength to the muscles. Duchene muscular dystrophy is caused by the absence of dystrophin in the age 30 years. Becker muscular dystrophy is the cause of the reduced amount of dystrophin protein present in the body. DMD is associated with these kinds of disorders. Mutations caused by the dystrophin gene located on the chromosomes Xp21.2 result in deletions, point mutations and partial gene duplication.

Therefore the correct option is (A).

Note:
The structure of the dystrophin protein is rod shaped cytoplasmic that is located in the primary skeletal of the muscles and cardiac muscles. Dystrophin gene is caused to change with the help of DMD. The average human protein coding gene is 309 bp long exons, 67 kbp long human protein coding gene and 6355 bp long introns are present in it.