Question

Kupffer cell is present in
A. Liver
B. Pancreas
C. Kidney
D. Intestine

Answer 1

Hint: Kupffer cells are found attached to the endothelial cells of sinusoids. These kupffer cells behave as immune cells as they comprise a large number of macrophages present inside the body.

Complete answer:
Macrophages form a part of white blood cells. They are responsible for providing innate immunity to the body. Every organ of the body consists of different types of macrophages that kill microorganisms, cancerous cells, and engulfs foreign particles through phagocytosis. Kupffer cells are found in the liver. The Kupffer cells are amoeboid in shape. They are present inside the liver sinusoidal cells. Organs for projection, like lamellipodia, pseudopodia and microvilli are present on the surface of kupffer cells which perform the function of endocytosis. Inside the body, lethal substances removal and their detoxification is carried out through the liver. Kupffer cells are the large cells that are found attached at the hepatic sinusoidal lining inside the liver. They play a major role in removing the debris and pathogens entering the small intestine via hepatic portal vein. Hence the kupffer cells form an important part of the mononuclear phagocyte system by constituting the major portion of the tissue macrophages found inside the body.
On the other hand, Islets of Langerhans cells are present in pancreas; intestinal macrophages are present in intestine while monocyte-derived macrophages are present in kidneys.

Hence, the correct answer is option (A).

Note: Kupffer cells are also referred to as Kupffer–Browicz cells and stellate macrophages. They serve as the primary immune cells that counter the bacterial endotoxins, gut bacteria and debris of microbes that are being transported from the gastrointestinal tract to the liver through the hepatic portal vein. Therefore, any sort of malfunctioning in kupffer cells might be responsible for several liver diseases such as viral hepatitis, alcoholic liver disease, steatohepatitis , liver fibrosis, intrahepatic cholestasis and liver activation or rejection at the time of transplantation.