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In controlling the synthesis and secretion of aldosterone, which of the following factors is least important?
A. Renin
B. Angiotensin II
C. Concentration of plasma Na+
D. ACTH

Answer
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Hint: Aldosterone is the hormone produced by zona glomerulosa in the adrenal gland. It is used for sodium conservation in the kidney, salivary glands, sweat gland and colon. It is a steroid hormone. It is used to regulate salt and water in the human body and it affects the blood pressure. It affects the electrolyte balance in some parts of the body. It targets the kidney and it stimulates reabsorption of sodium and sodium and recreation of potassium and hydrogen ions.

Complete answer:
Four factors that are involved in the aldosterone secretion and synthesis are potassium, sodium, angiotensin II and ACTH. ACTH is least interacting in this synthesis and secretion. The secretion is regulated by renin- angiotensin. It is an enzyme.
Option A Renin: Renin is the enzyme. It is part of the kidneys and it regulates blood pressure. In blood renin acts on angiotensinogen called protein substance that results in release of angiotensin I. Renin is in the aldosterone system. It is used to regulate blood pressure, fluid level and electrolyte balance and also the systemic vascular resistance.
Hence option A is incorrect.
Option B Angiotensin II: Angiotensin II also acts on adrenal cortex in zona glomerulosa. In this place it stimulates release of aldosterone. Aldosterone is called as a steroid hormone it increases the sodium reabsorb and potassium excretion in nephron. It triggers the release of aldosterone in adrenal gland and vasopressin from the pituitary gland.
Hence option B is incorrect.
Option C Concentration of plasma \[N{a^ + }\]: Concentration of plasma \[N{a^ + }\] is affecting the body by regulating blood pressure. It sends the signal to the colon to the colon and kidney in the human body. So, it will increase the amount of sodium levels in the body.
Hence option C is incorrect.
Option D ACTH: ACTH is the adrenocorticotropic hormone. It releases from the pituitary and acts on the adrenal gland. It is also used to release cortisol and also acts on gluconeogenesis. It also controls stress. The process is aldosterone released from adrenal gland by the renin act on angiotensinogen. It is converted into angiotensin I and angiotensin II. It stimulates the secretion of aldosterone.
Hence option D is correct.

Therefore, Option D) ACTH is the correct answer.

Note:
Aldosterone regulates salt and water balance in the body by gain or loss sodium level in kidneys. Aldosterone located above the kidneys. The stress level is increased when changes in the aldosterone production in the body. It affects the mood of humans. Salt is taken higher than the production of aldosterone will increase. Hormone production is controlled by ACTH.