Question

If you suspect a major deficiency of antibodies in a person, which of the following would you look for confirmatory evidence?
A)Serum globulins
B)Fibrinogen in plasma
C)Serum albumins
D)Haemocytes

Answer 1

Hint: It is made in our liver by our immune system. It also plays an important role in fighting infection. It includes enzymes and antibodies. It comprises all the proteins which are not used for blood clotting.

Complete answer:
-Antibodies are a group of globular proteins consisting of Serum/ plasma. Thus, they are also known as Immunoglobulin. It inactivates the antigen.
-Serum does not have WBC (leukocytes), RBC(erythrocytes), Platelets, and other clotting factors.
-17-20% of the total protein is being formed by antibodies in the blood serum.
-based on the properties serum globulin are of four types-
1)alpha 1 globulins
2)alpha 2 globulins
3)beta globulins
4)gamma globulin
Antibodies belong to the gamma globulin class. These antibodies play a very important role in various medications and therapeutic purposes. These antibodies are immunologically very active. So they are also called immunoglobulin. Their deficiency can cause many diseases (gammopathy) and also not good for health so they are very important parts of human blood.
-Therefore, to know whether the person has a deficiency of antibodies or not, serum globulin is tested.

Additional Information: -To produce Gamma globulins in the patient injections were given to boost their immunity.
-We can easily identify the position of Gamma globulin in the blood with a process called electrophoresis. It is done for the extraction of serum protein. Gamma globulins are a very common habit so they take time to segregate during electrophoresis.
Fibrinogen in plasma- fibrinogen is a plasma protein that is responsible for normal blood clotting.
Serum albumin- it is a protein which is present in human blood plasma in very large quantities. Its important role is to balance tissue fluid and also the regulation of plasma volume.
Haemocyte- it's important role is, it works as an immune defense system.

So, the correct answer is, "Serum globulin".

Note: Globulins are processed in the liver by our immune system. It plays an important function in the liver, also helps in blood clotting, and fights against infection. Globulins have higher molecular weights than albumins and belong to the family of globular proteins. They are not soluble in distilled water but are soluble in dilute salt solutions.