Question

If a person is suffering from a disease of muscular dystrophy, he will eliminate one of the following in large amounts in his urine.
A. Sulfates
B. Glucose
C. Creatinine
D. Water

Answer 1

Hint: Muscular dystrophy is a disease that affects the muscles present in the body. It damages and weakens the muscles as the disease progresses. Muscles require dystrophin protein to carry out their function and due to lack of this dystrophin protein, a person shows the symptoms of muscular dystrophy.

Complete answer:
Muscular dystrophy is an inherited disease (X – linked recessive/ dominant). It affects skeletal muscles. This disease can occur at any point in time in life. Young boys are more likely to develop this disease compared to girls. The symptoms of muscular dystrophy include frequent falls, large calf muscles, learning disabilities, difficulty getting up, muscle pain, and stiffness. Dystrophin protein which is being mutated in this disease links the actin with cytoskeletal. This protein also regulates calcium levels. Creatinine is an end product of muscle metabolism. Due to muscular dystrophy, the metabolism isn’t carried out properly and it will decrease the amount of creatinine in the blood. The amount of creatinine present in the blood is directly proportional to the amount of creatinine present in urine.
So, if the person is having muscular dystrophy, he will eliminate creatinine in his urine in a large amount.

The correct answer is option (C).

Note:
Two major types of muscular dystrophies can be seen such as BMD (Becker muscular dystrophy) and DMD (Duchenne muscular dystrophy). Muscular dystrophies can occur due to a mutation in a gene that codes for dystrophin protein. The levels of creatinine are higher in BMD when compared to DMD. These creatinine levels reflect the severity of the disease, the lesser the creatinine levels, the severe the disease.