Question

Explain the auto regulatory mechanism of GFR.

Answer 1

Hint: Assessment of kidney function takes place in various ways. Using the presence of symptoms, along with signs as well as certified measurements using urine tests, blood tests, and medical imaging.

Complete answer:
Performance and Functions of a healthy kidney consists of maintaining a person's fluid balance, maintaining an acid-base balance; along with regulating electrolytes including sodium, as well as potassium, other electrolytes; clearing toxins; and regulating blood pressure; regulating hormone, for instance erythropoietin; and activation of vitamin D.

The auto regulatory mechanism by which human kidney regulates and performs its functions is glomerular filtration rate is auto regulative. It is carried out by the juxtaglomerular apparatus. Juxtaglomerular apparatus is a microscopic structure located between the vascular pole of the renal corpuscle and the returning distal convoluted tubule of the same nephron. It plays a role in regulating the renal blood flow and glomerular filtration rate (GFR).

When there is a fault in the glomerular filtration rate, the kidneys activate the juxtaglomerular cells to release renin. This activates the glomerular blood flow, thereby bringing the Glomerular Filtration Rate back to its normal level. The release of Renin brings the GFR back to the normal point by the activation of the renin-angiotensin mechanism.

Note: Glomerular filtration rate (GFR) is considered to be the best overall index of body kidney function. A Normal Glomerular Filtration Rate varies according to a person’s age, sex, as well as body size, along with declines with age. The National Kidney Foundation has suggested using the CKD-EPI Creatinine Equation (2009) to estimate the Glomerular Filtration rate.