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How did Charles V respond to the Protestant Reformation?

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Hint: Protestantism, the Christian religious movement that originated in the early 16th century in northern Europe in response to mediaeval Roman Catholic doctrines and practises.

Complete answer: We need to go back to the early 16th century, when there was only one church in Western Europe, to grasp the Protestant Reform movement, what we will now call the Roman Catholic Church. Protestantism is one of three main movements of Christianity, along with Roman Catholicism and Eastern Orthodoxy. It spread throughout the globe after a series of European religious wars in the 16th and 17th centuries, and especially in the 19th century.
The first attempt to avoid the spread of Protestantism was to label a heresy the effort to reform the Catholic Church. The Holy Roman Emperor, Charles V, in 1521, demanded that Luther appear at Worms before the Holy Roman Empire's diet. Between church and state, there was no separation. Luther declined and he was put as an outlaw under an imperial ban.

Charles V revitalised the universal monarchy's mediaeval concept and spent much of his life protecting from the Protestant Reformation the legitimacy of the Holy Roman Empire, the expansion of the Ottoman Empire, and a series of wars with France.
In 1521, Charles V, the Holy Roman Emperor, requested that Luther appeared before the Holy Roman Empire's diet at Worms. There was no distinction between the state and the church. Luther refused and he was placed under an imperial ban as an outlaw.

Note: The Reformation led to the reformulation of some core tenets of Christian belief and culminated in the separation between Roman Catholicism and the modern Protestant traditions of Western Christianity.