Question

Where are clotting proteins produced?

Answer 1

Hint: Fibrinogen, also known as clotting protein, is a glycoprotein complex produced in the liver and found in the blood of all vertebrates. It is transformed enzymatically by thrombin to fibrin and ultimately to a fibrin-based blood clot during tissue and vascular injury. Fibrin clots are typically used to halt bleeding by occluding blood arteries. Fibrin binds to thrombin and inhibits its action.

Complete answer:
The clotting protein, also known as fibrinogen, is a protein that helps the body create blood clots. It is produced in the liver and results in the formation of fibrin. Fibrin is the major protein in a blood clot that aids in wound healing and hemorrhage control. Patients with certain types of cancer or other diseases may have higher-than-normal levels of fibrin-like compounds in their blood and urine. The level of these compounds in the body can be measured to see how well cancer treatment is functioning or if the cancer has progressed. Fibrinogen is a tumour marker that is found in the blood.
The liver produces fibrinogen, which is then released into the bloodstream along with many other clotting factors (also called coagulation factors). When a body tissue or blood vessel wall is wounded, hemostasis kicks in to assist stop the bleeding by producing a plug at the injury site. Platelets, which are small cellular fragments, cluster and cling to the injury site, and clotting factors are activated one by one. The coagulation cascade is the name for the last part.

So, the right answer is Liver.

Note:
Soluble fibrinogen is transformed into insoluble fibrin threads as the cascade progresses. These threads subsequently crosslink to form a fibrin net at the damage site, which stabilizes it. The fibrin net, together with the platelets, attaches to the damage site and forms a stable blood clot. This barrier stops further blood loss and stays in place until the damaged area heals.