Question

Which of the following is correct for the origin of lysosome(L)?
A. ER → Golgi bodies → L
B. Golgi bodies → ER → L
C. Nucleus → Golgi bodies → L
D. Mitochondria → ER→ Golgi bodies → L

Answer 1

Hint: The origin of lysosome means the biogenesis of lysosome.
The biogenesis of lysosome requires special lysosomal hydrolases and membrane proteins which are synthesized in the endoplasmic reticulum.

Complete step by step answer:
Then it is transported from the trans Golgi network to an intermediate compartment by means of transport vesicles. The transport vesicles are coated by clathrin protein.
The lysosomal enzymes are glycoproteins, containing N- Linked oligosaccharides that are processed in a unique way in the cis- Golgi network that segregates so that their mannose residues are phosphorylated.

The mannose 6- phosphate(M6P) groups are recognized by M6P receptors in the trans Golgi network that segregates the hydrolases and helps them to package them into budding clathrin – coated vesicles which quickly lose their coats.
The transport vesicles containing the M6P- receptors act as shuttles that move the receptors back and forth between the trans Golgi network and Endolysosomes.
The low pH in the endolysosome helps to dissociate lysosomal hydrolases from this receptor. It makes the transport of the hydrolases unidirectional.

So, the answer is A. ER → Golgi bodies → L


Note:
Lysosomes help in autolysis of various organelles of the cells.
Lysosome digests extracellular and intracellular particles.