Question

What will be the glomerular filtration pressure (GFP), if the glomerular hydrostatic pressure (GHP) is \[60mmHg\], blood colloid osmotic pressure, (BCOP) is \[30mmHg\] and capsular hydrostatic pressure (CHP) is \[20mmHg\]?
A. \[50mmHg\]
B. \[30mmHg\]
C. \[70mmHg\]
D. \[10mmHg\]

Answer 1

Hint: The glomerular filtration rate is the amount of blood filtered by the kidney's glomerulus into the Bowman's capsule per unit of time. It is sometimes abbreviated as GFR. This rate of filtration is influenced by the interplay of several important forces.

Complete answer: In the given question, the Glomerular Filtration pressure (GFP) is to be calculated. Where the following are given;
 The Glomerular hydrostatic pressure(GHP) = \[60mmHg\]
The Blood colloid osmotic pressure(BCOP) = \[30mmHg\]
The capsular hydrostatic pressure (CHP) - \[20mmHg\].
To find the GFP, the formula is Glomerular Filtration rate = GHP - ( BCOP + CHP)
                                                   \[ = 60 - (30 + 20)\]
                                                    \[ = 10mmHg\]
The pressure at which the filtrate passes through the glomerulus is called the Glomerular Filtration Pressure. The passive process by which water and small dissolved solute molecules, including smallest proteins are forced through the fenestrations of the capillary tuft within the renal corpuscle, and through the endothelial capsular membrane. The filtration slits formed by the pedicel of the podocytes, and into the capsular space; the main driving force is the glomerular blood hydrostatic pressure, is known as the Glomerular filtrate. It consists of water and small dissolved solutes in relatively equal concentrations to their concentration in the blood plasma. The GFR is determined by four mechanisms: renal autoregulation, hormonal regulation by the renin-angiotensin system, hormonal regulation by the antagonistic interplay of aldosterone and atrial natriuretic peptide (ANP) and neuronal regulation by the autonomic nervous system.
Hence, the correct answer is option D.

Note: The total amount of plasma filtrate formed by all nephrons of the kidneys per minute; it is determined physiologically by three factors; the total surface area available for filtration, the permeability of the filtration membrane and the net filtration pressure.