Question

Jacob and Monod named those enzyme allosteric, whose activity is regulated by
(a) Substrate
(b) Prosthetic group
(c) Coenzyme
(d) End product

Answer 1

Hint: The activity of some enzyme is regulated by the final product of a series of changes or processes. Also, we can say that these are the products which remain as the result of the series of activities done.

Complete answer:
The biologist Jacob and Monod named those enzymes allosteric, whose activity is regulated by the end product. The allosteric enzyme is that enzyme whose activity is modified by the non-covalent binding of an allosteric effector at a site other than the active site. This binding mediates the conformational changes altering its catalyst or binding properties.

Additional Information:
- The term allosteric has been introduced by Jacob and Monod to denote an enzyme site different from the active site.
- These enzymes have one or more allosteric sites that are binding sites different from enzyme active sites.
- The effector or modulator are the molecules that bind the allosteric sites. The effector may be positive or negative and regulate the enzyme activity.
- When a positive allosteric effector binds at the allosteric site the activity of the enzyme is increased and the site is known as the activator site.
- On the other hand, when a negative allosteric effector binds at the allosteric site the activity of the enzyme is inhibited and the site is known as the inhibitor site.
- Allosteric behavior itself was often observed for regulatory or control enzymes of metabolic pathways and formed the idea for feedback inhibition and activation, such enzymes were called allosteric by Jacob and Monod.
So, the correct answer is '(d) End product'.

Note:
- The allosteric enzyme is that enzyme whose activity is modified by the non- covalent binding of an allosteric effector.
- The term allosteric has been introduced by Jacob and Monod to denote an enzyme site different from the active site.
- The effector or modulator are the molecules that bind the allosteric sites. The effector may be positive or negative and regulate the enzyme activity.
- Allosteric behavior itself was often observed for regulatory or control enzymes of metabolic pathways and formed the idea for feedback inhibition and activation, such enzymes were called allosteric by Jacob and Monod.