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In which stage of the cell cycle, histone proteins synthesized in eukaryotic cells?
A) During the $G_2$ stage of prophase
B) During S phase
C) During entire prophase
D) During telophase

Answer
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Hint: Cell division is a process that is necessary for the growth and development of the organism. The cells of an organism divide to make newer cells and lead to the growth of the organism or tissue. The histone protein provides structural support to the chromosome and makes it condensed.

Complete Answer:
- The entire process of cell division is called the cell cycle. Each cell cycle is a four-step process. The four stages are $G_1$, S, $G_2$, and M.
- The $G_1$ and $G_2$ gap 1 and gap 2 respectively are preparatory phases in which the cell prepares itself for the next steps.
(I) The S stage is for synthesis. In this phase, the genetic material or the DNA gets replicated.
(II) The $G_1$ s, and $G_2$ are called interphase collectively. Interphase is the time duration between two successive divisions.
(III) The M phase is for mitosis or the actual cell division. The synthesis of histone protein occurs during the synthesis phase or the S phase.

So ‘During S phase’ the correct answer.

Additional information: The M phase is divided into two subphases. The mitosis and cytokinesis. The mitosis is a phase in which prepares for the actual cell-division. The four stages of mitosis are prophase, metaphase, anaphase, and telophase

Note: The synthesis occurs only during the synthesis phase. The prophase and telophase are the last stages of mitosis. For the synthesis of new DNA molecules in the replication process, histone proteins are a prerequisite as they are an important part of DNA assembly.