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In cell division spindle fiber is made up of protein.
A. Myoglobin
B. Tubulin
C. Albumin
D. Myosin

Answer
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Hint: Spindle fiber are filaments that form the mitotic spindle in the cell division. The spindle is necessary to equally divide the chromosomes in a parental cell into two daughter cells during both types of nuclear division: mitosis and meiosis.

Complete Answer:
- The process of cell division is the mitotic spindle, which partitions a complete set of chromosomes to each daughter cell. The spindle consists of microtubules, polar dynamic fibers that polymerize from tubulin subunit, as well as hundreds of other proteins that function together to orchestrate chromosome segregation. This includes a large set of microtubule based motor proteins that use ATP hydrolysis to generate movement, or alter microtubule dynamics.
- While the basic steps of spindle assembly and anaphase chromosome segregation have been documented since the emergence of light microscopy, pioneering techniques or microtubule dynamics. Molecular approaches empowered by complete genome sequence are continuing to identify the protein responsible for the phenomena observed.
- The tubulin family of proteins is a vital component of the Eukaryotic cytoskeleton and are the main constituent of microtubules in the living cells.
- The tubulin protein alpha and beta polymerize into long chains or filaments that form microtubules, an essential element of Eukaryotic cytoskeleton. The microtubule plays a crucial role in the cell support and cell movement, making tubulin imperative to normal cell function.

Therefore, from the above explanation, the correct option is (B) Tubulin.

Note: Through being a fundamental component of the cell’s cytoskeleton, tubulin is also crucial to the cell’s interaction with other organelle, and its movement. The cytoskeleton connects to every part of the cell membrane and every organelle. Tubulin and other filaments are known to be responsible for the movements of the cell membrane, organelles and cytoplasm.