Answer
Verified
333.8k+ views
Hint: To determine the answer to this question we should know the structure of phenol and aspirin so, we can determine what changes in the reactant we have to do. We should also know the function of some simple acid and bases such as carbon dioxide and sodium hydroxide.
Complete solution:
The structure of phenol is as follows:
The structure of aspirin is as follows:
Aspirin has one carboxylic group, so we have to add a carboxylic group to phenol. We will use the Kolbe-Schmitt reaction for this. The Kolbe-Schmitt reaction is a carboxylation reaction. The heating of phenol with sodium hydroxide and carbon dioxide is known as Kolbe-Schmitt reaction. Kolbe-Schmitt reaction is an additional type reaction.
The base abstract a proton from the hydroxide group of the phenol generating a negative charge on oxygen. Delocalization of negative charge generates a carbon nucleophile. Which attacks on carbon dioxide. The protonation give the product having carboxylic group.
The product of Kolbe-Schmitt reaction is salicylic acid.
We will treat the salicylic acid with acetic anhydride for the preparation of aspirin as follows:
The above reaction is known as acetylation of salicylic acid. The acetylation of salicylic acid take place in presence of strong acid like sulphuric acid.
The salicylic acid reacts with acetic anhydride in presence of sulphuric acid to form acetylated salicylic acid and acetic acid.
Therefore, we can convert phenol to aspirin by treating phenol with sodium hydroxide and carbon dioxide in an acidic medium. Then treated the product salicylic acid with acetic anhydride.
Note:The molecular formula of aspirin is ${{\text{C}}_{\text{9}}}{{\text{H}}_{\text{8}}}{{\text{O}}_{\text{4}}}$. It is soluble in water. The acetylsalicylic acid is known as aspirin. It is a drug used as a pain reliever or in fever. It has adverse effects that upset the stomach. In presence of moisture aspirin hydrolysed into salicylic acid and acetic acid. Aspirin is stable in dry air. The formation of aspirin from salicylic acid is an esterification reaction.
Complete solution:
The structure of phenol is as follows:
The structure of aspirin is as follows:
Aspirin has one carboxylic group, so we have to add a carboxylic group to phenol. We will use the Kolbe-Schmitt reaction for this. The Kolbe-Schmitt reaction is a carboxylation reaction. The heating of phenol with sodium hydroxide and carbon dioxide is known as Kolbe-Schmitt reaction. Kolbe-Schmitt reaction is an additional type reaction.
The base abstract a proton from the hydroxide group of the phenol generating a negative charge on oxygen. Delocalization of negative charge generates a carbon nucleophile. Which attacks on carbon dioxide. The protonation give the product having carboxylic group.
The product of Kolbe-Schmitt reaction is salicylic acid.
We will treat the salicylic acid with acetic anhydride for the preparation of aspirin as follows:
The above reaction is known as acetylation of salicylic acid. The acetylation of salicylic acid take place in presence of strong acid like sulphuric acid.
The salicylic acid reacts with acetic anhydride in presence of sulphuric acid to form acetylated salicylic acid and acetic acid.
Therefore, we can convert phenol to aspirin by treating phenol with sodium hydroxide and carbon dioxide in an acidic medium. Then treated the product salicylic acid with acetic anhydride.
Note:The molecular formula of aspirin is ${{\text{C}}_{\text{9}}}{{\text{H}}_{\text{8}}}{{\text{O}}_{\text{4}}}$. It is soluble in water. The acetylsalicylic acid is known as aspirin. It is a drug used as a pain reliever or in fever. It has adverse effects that upset the stomach. In presence of moisture aspirin hydrolysed into salicylic acid and acetic acid. Aspirin is stable in dry air. The formation of aspirin from salicylic acid is an esterification reaction.
Recently Updated Pages
Basicity of sulphurous acid and sulphuric acid are
Three beakers labelled as A B and C each containing 25 mL of water were taken A small amount of NaOH anhydrous CuSO4 and NaCl were added to the beakers A B and C respectively It was observed that there was an increase in the temperature of the solutions contained in beakers A and B whereas in case of beaker C the temperature of the solution falls Which one of the following statements isarecorrect i In beakers A and B exothermic process has occurred ii In beakers A and B endothermic process has occurred iii In beaker C exothermic process has occurred iv In beaker C endothermic process has occurred
What is the stopping potential when the metal with class 12 physics JEE_Main
The momentum of a photon is 2 times 10 16gm cmsec Its class 12 physics JEE_Main
How do you arrange NH4 + BF3 H2O C2H2 in increasing class 11 chemistry CBSE
Is H mCT and q mCT the same thing If so which is more class 11 chemistry CBSE
Trending doubts
Difference Between Plant Cell and Animal Cell
Difference between Prokaryotic cell and Eukaryotic class 11 biology CBSE
What is BLO What is the full form of BLO class 8 social science CBSE
Fill the blanks with the suitable prepositions 1 The class 9 english CBSE
The Equation xxx + 2 is Satisfied when x is Equal to Class 10 Maths
Write a letter to the principal requesting him to grant class 10 english CBSE
Write two differences between autotrophic and heterotrophic class 10 biology CBSE
Angle inscribed in a minor segment is A acute B obtuse class 10 maths CBSE
Explain land use pattern in India and why has the land class 8 social science CBSE