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Fill in the blank with the most appropriate preposition-
  Her father died ______ cancer.
A) of
B) with
C) at
D) in

Answer
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Hint: A preposition is a word or a phrase that is used before a noun or a pronoun to show place, time or direction.

Complete answer:
In English language, a preposition is a word or a phrase that typically combines with a noun phrase to form a phrase. When using a preposition, it must always have the subject before, and follows with a noun. For example : I lost the game to him.
Now, let us examine all the given options so that we can find out the correct answer :
Option ‘a' is of. You use it to show a connection or a belonging. Of expresses the part of something of its whole. For example : He is a boy of 15.
Option 'b' is With. You use it to talk about the connection between the people and things. For example : I am going on a holiday with my friends next month.
Option 'c' is At. You use at when referring to a building as locations in a city. For example : Meet me at the hotel.
Option 'd' is In. You use In when something is located inside of a defined space. For example : She is in her room.

As we know the meaning of all options given, we can easily figure out the answer. The correct answer is of. The complete sentence would be, Her father died of cancer. Hence, the correct answer is option 'a', of.

Note : Prepositions combine with nouns to form a phrase.