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Hint: \[LiAl{H_4}\] is a very strong reducing agent. It reduces aldehydes, amides, ketones, esters, carboxylic acid and even carboxylate salts to alcohols.
Amide is a functional group that contains both nitrogen and carboxyl groups in it. It is usually represented as below:
\[LiAl{H_4}\] will reduce Amides to Amines and this means that the oxygen that was present in the amide is removed from the molecule after the reaction completes.
Complete answer:
Let’s see how the reaction occurs when amide is treated with \[LiAl{H_4}\]
First there is a nucleophilic attack by one of the hydrides of \[LiAl{H_4}\] . Because the carbonyl group is highly polar the oxygen becomes negative and thus \[Al\] having negatively charge can now attack the positively charged carbonyl carbon and thus the following step occurs
Now since there is an oxygen that can act as a leaving group we will get the following reaction which leads to the formation of an iminium ion
Now there is a nucleophilic attack by the hydride of \[LiAl{H_4}\] causing for the formation of the final product, amine
That is given by the following reaction:
Thus we get Amine as the product when amides are treated with \[LiAl{H_4}\] which is a strong reducing agent.
Thus we can write the general form of the reaction as:
Note:
\[NaB{H_4}\] is also a reducing agent but it is very less reactive than \[LiAl{H_4}\]. \[NaB{H_4}\] can reduce aldehydes, ketones and acid chlorides but cannot reduce amides or esters.
Amides can be converted to \[{1^o},{\text{ }}{2^o}{\text{ or }}{3^o}\]amine just by using \[LiAl{H_4}\]. For doing this we have to select the suitable amides to begin the reaction with.
The purpose of using \[{H_2}O\] at the end is for a bit of workup. It neutralizes strongly basic reagents at the end of the reaction thus helping in the rate of the reaction.
Amide is a functional group that contains both nitrogen and carboxyl groups in it. It is usually represented as below:
\[LiAl{H_4}\] will reduce Amides to Amines and this means that the oxygen that was present in the amide is removed from the molecule after the reaction completes.
Complete answer:
Let’s see how the reaction occurs when amide is treated with \[LiAl{H_4}\]
First there is a nucleophilic attack by one of the hydrides of \[LiAl{H_4}\] . Because the carbonyl group is highly polar the oxygen becomes negative and thus \[Al\] having negatively charge can now attack the positively charged carbonyl carbon and thus the following step occurs
Now since there is an oxygen that can act as a leaving group we will get the following reaction which leads to the formation of an iminium ion
Now there is a nucleophilic attack by the hydride of \[LiAl{H_4}\] causing for the formation of the final product, amine
That is given by the following reaction:
Thus we get Amine as the product when amides are treated with \[LiAl{H_4}\] which is a strong reducing agent.
Thus we can write the general form of the reaction as:
Note:
\[NaB{H_4}\] is also a reducing agent but it is very less reactive than \[LiAl{H_4}\]. \[NaB{H_4}\] can reduce aldehydes, ketones and acid chlorides but cannot reduce amides or esters.
Amides can be converted to \[{1^o},{\text{ }}{2^o}{\text{ or }}{3^o}\]amine just by using \[LiAl{H_4}\]. For doing this we have to select the suitable amides to begin the reaction with.
The purpose of using \[{H_2}O\] at the end is for a bit of workup. It neutralizes strongly basic reagents at the end of the reaction thus helping in the rate of the reaction.
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